Technology Gas chromatography Protection strategy Product authentication Type Analytical technique System Laboratory based Medium Medicine Authentication/Identificaton Authentication Traceability No Cost Price on request Required equipment Gas chromatography apparatus, solvents Vertification level Laboratories N.B. GC-MS portable device exists. GC can only be used for separation of volatile materials, the compounds need to be gaseous in the analytical temperature range. Typically Gc is used for separation of residual solvents, undeclared ingredients, volatile impurities. Some compounds are too unstable for GC (anemisinin derivate for treating malaria for example). Description GC is a chromatographic technique used to separate the different compounds of a sample. The sample (dissolution in solvents needed) is injected in the apparatus, pushed through a thin column by a gas, the column contains a stationary phase and the gas is the mobile phase. The different constituents interact with the two phases, this interaction is going to determine their rate of progress. The retention time of the constituent is distinctive for a given molecule in the same analytical system. Different detectors can be used, the most effective and sensitive being the combination GC-MS Strengths Identification of the different constituents of a sample, Can be used for profiling, Unequivocal identification of complex pharmaceutical samples when coupled with a mass spectrometer Limitations Cost, Requires equipment + formation, Destructive of the sample, Time consuming Links:
Technology Gas chromatography
Protection strategy Product authentication
Type Analytical technique
System Laboratory based
Medium Medicine
Authentication/Identificaton Authentication
Traceability No
Cost Price on request
Required equipment Gas chromatography apparatus, solvents
Vertification level Laboratories
N.B. GC-MS portable device exists. GC can only be used for separation of volatile materials, the compounds need to be gaseous in the analytical temperature range. Typically Gc is used for separation of residual solvents, undeclared ingredients, volatile impurities. Some compounds are too unstable for GC (anemisinin derivate for treating malaria for example).
Description GC is a chromatographic technique used to separate the different compounds of a sample. The sample (dissolution in solvents needed) is injected in the apparatus, pushed through a thin column by a gas, the column contains a stationary phase and the gas is the mobile phase. The different constituents interact with the two phases, this interaction is going to determine their rate of progress. The retention time of the constituent is distinctive for a given molecule in the same analytical system. Different detectors can be used, the most effective and sensitive being the combination GC-MS
Strengths Identification of the different constituents of a sample, Can be used for profiling, Unequivocal identification of complex pharmaceutical samples when coupled with a mass spectrometer
Limitations Cost, Requires equipment + formation, Destructive of the sample, Time consuming
Links:
Technology Gas chromatography
Protection strategy Product authentication
Type Analytical technique
System Laboratory based
Medium Medicine
Authentication/Identificaton Authentication
Traceability No
Cost Price on request
Required equipment Gas chromatography apparatus, solvents
Vertification level Laboratories
N.B. GC-MS portable device exists. GC can only be used for separation of volatile materials, the compounds need to be gaseous in the analytical temperature range. Typically Gc is used for separation of residual solvents, undeclared ingredients, volatile impurities. Some compounds are too unstable for GC (anemisinin derivate for treating malaria for example).
| Description | GC is a chromatographic technique used to separate the different compounds of a sample. The sample (dissolution in solvents needed) is injected in the apparatus, pushed through a thin column by a gas, the column contains a stationary phase and the gas is the mobile phase. The different constituents interact with the two phases, this interaction is going to determine their rate of progress. The retention time of the constituent is distinctive for a given molecule in the same analytical system. Different detectors can be used, the most effective and sensitive being the combination GC-MS |
| Strengths | Identification of the different constituents of a sample, Can be used for profiling, Unequivocal identification of complex pharmaceutical samples when coupled with a mass spectrometer |
| Limitations | Cost, Requires equipment + formation, Destructive of the sample, Time consuming |
| Links: |